Protease Inhibitors and Phosphatase Inhibitors
Cayman Chemical DXR InhIbItr 11afree acId 5mg
An inhibitor of P. falciparum DXR (IC50 = 0.11 µM); inhibits the growth of P. falciparum in isolated human erythrocytes (IC50 = 0.37 µM)
Cayman Chemical CathepsIn L InhIbItr 10mg
A potent cathepsin L inhibitor (IC50 = 0.85 nM); selective for cathepsin L over calpain II and cathepsin B (IC50s = 184, and 85.1 nM, respectively); trypanocidal against T. brucei (ED50 = 45 nM); completely suppresses osteoclastic pit formation on femur slices isolated from bovine cortical bone at a concentration of 1 μg/ml; inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner
Abcam Serine Protease Assay Kit (FAM-Phe-DAP), 25 Tests
These Serine Protease Assay Kits enable researchers to detect intracellular chymotrypsin-like serine protease activity in vitro without lysing the cell.
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC R406 (free base) 10mg 841290-80-0
R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. R406 (free base) triggers apoptosis. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Rigosertib sodium salt, 1225497-78-8, MFCD11655911, 5 mg
MF: C21H24NNaO8S, MW: 473.47, Synonyms: ON-01910, Estybon. Solubility: 23.65mg/mL in DMSO. Rigosertib (ON-01910,Estybon) is a potent, specific PLK1 inhibitor with IC50 value of 9nM.
CPC Scientific Biotin-Tyr-Val-Ala-Asp-CMK 0.5MG
Biotinylated analog of the caspase-1 inhibitor.ONE-LETTER SEQUENCE: Biotin-YVAD-CMKMOLECULAR FORMULA: C32H45Cl1N6O9S1MOLECULAR WEIGHT:725.27STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [402474-75-3], SYNONYMS: Biotinyl-Tyr-Val-Ala-Asp-chloromethylketoneRESEARCH AREA: ApoptosisREFERENCES: Y.A. Lazebnik et al., Nature, 371, 346 (1994)
Apexbio Technology LLC Cell-permeable, irreversible pan-caspase inhibitor 1135695-98-5. MFCD08669741
Cell-permeable, irreversible pan-caspase inhibitor 1135695-98-5. MFCD08669741
Research Products International Corp Aprotinin, Bovine Lung, 50 Milligrams
Competitive serine protease inhibitor which forms stable complexes with and blocks the active sites of enzymes. The binding is reversible, and most aprotinin-protease complexes dissociate at a pH>10 or <3.2. Target enzumes include trypsin, chymatrypsin, kalikrein and plasmin.
Activity: >4500 KIU/mg
Apexbio Technology LLC Cell-permeable, irreversible pan-caspase inhibitor 187389-52-2. MFCD02684037
Cell-permeable, irreversible pan-caspase inhibitor 187389-52-2. MFCD02684037
Abcam FH-535, Wnt/beta-cantenin inhibitor, 10MG
MW 361.2 Da, Purity >98%. Wnt/β-cantenin inhibitor and PPARγ and PPARδ antagonist. Suppresses proliferation of cancer cells in vitro. Antitumor agent.
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences Tyrphostin AG 1478 (5mg). CAS: 153436-53-4
EGFR inhibitor. Potent and selective inhibitor of EGFR (IC50 = 3nM). Reduces EGF-stimulated DNA synthesis in Rat-1 fibroblasts by ~75% at 0.25μM. Blocks EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction in A431 cells. Also inhibits H2O2-induced stimulation of amphiregulin expression in rat gastric epithelium (RGM 1) cells. Alternative name: 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline. Formula: C16H14ClN3O2. MW: 315.8. Purity: ≥98% (HPLC). Appearance: White to light yellow solid. Solubility: Soluble in DMSO (10mg/ml). Long Term Storage: -20°C. Handling: Protect from light. Packaged under inert gas.
![Research Products International Corp PMSF [Phenylmethylsulfonyl fluoride], 5 Grams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-P20270-5.0.JPG-250.jpg)
Research Products International Corp PMSF [Phenylmethylsulfonyl fluoride], 5 Grams
Irreversible serine protease inhibitor of chymotrypsin, kallikrein, papain, subtilisin, thrombin and trypsin. Working Conentration: 0.1-1.0mM.
Cayman Chemical PI3-KInase a InhIbItr 2hyd 1mg
An inhibitor of PI3K p110α (IC50 = 2 nM in an enzyme assay); selective for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively); inhibits mTOR (IC50 = 49 nM); inhibits proliferation in A375 melanoma cells (IC50 = 0.58 μM)
Sigma Aldrich Fine Chemicals Biosciences SUMO Protease His tagged r
SUMO proteases are a general class of enzymes that specifically remove the post-translational protein modification (PTM) known as small ubiquitin-related modifier (SUMO) which falls into the PTM class of ubiquitin and/or ubiquitin-like proteins (UBL). The enzyme commonly referred to as SUMO protease is the Ubl-specific protease 1 (Ulp1) from Saccharomyces cerevisiae. This was the first of this class of enzymes to be isolated. SUMO protease specifically cleaves the SUMO moiety in a scarless manner. SUMO protease recognizes the tertiary structure of the Ubiquitin-like SUMO domain and hydrolyzes the peptide bond in the x-Gly-Gly-x sequence after the Gly-Gly bond at the C-terminus of the SUMO domain. In addition to cleavage of natural SUMO-modified proteins SUMO protease is used to cleave recombinant SUMO fusion proteins. The SUMO domain is a known solubility-enhancing fusion tag used in recombinant protein expression. A histidine tag can also be added at the N-terminus of the SUMO doma
Cayman Chemical Aurora KInase InhIbItr III 1mg
A potent inhibitor of Aurora A kinase (IC50 = 42 nM); selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively)